Sometimes I think I'm really, really lucky that I can't take most drugs. Ibuprofen makes me higher than a kite. I occasionally take aspirin, acetaminophen doesn't seem to do anything for me so I skip it. I know someone who developed kidney cancer, they removed her kidney then 4 yrs later found it had metastasized throughout her body. I suspect her use of arthritis medications and NSAIDs were a contributing factor. She and her son have both had spinal fusion surgery and were told not to take ibuprofen because it inhibits bone growth but aspirin was OK.