The simply soft stuff is great - homespun and the red-heart version baby clouds, if you don't knit too tightly do very well too. I don't like the red-heart worsted, but I don't mind the wool=ease worsted at all.
I think you need to tailor what you are using toward your end user. I agree, a new parent does not want a hand wash blanket. How many of us have seen those acryic knitted or crochet blankets that our kids literally loved and used to rags? They don't consider them scratchy at all!