Oh boy..there are soooo many charities it'll make your head spin.
Here's a few I've knit for:
Afghans for Afghans
Knit for Kids
Caps to the Capitol (ends Jan 2nd)
I don't have anything specifically for your area, but if you don't want to mail items you could contact a local hospital and ask about chemo and preemie hats. Also your LYS may have information as well.
Here's some other links I have bookmarked.
Snuggles Project
Knitting for Charity list from Daily Knitter
Knitting for a Better World