Not at all. I knit with the yarn in my right hand for everything.
When you are knitting with two circs, it's just like regular knitting. It works out that you knit one side of the item, then turn it around and knit the other side.
The circs allow you to move the points to the end where you need them and the cords give you the flexibility to do that.
Once you actually do it the big AHA light goes on.