I just finished an afghan holding 5 strands together, using speed sticks. I found the best way to keep from having tangles, was to stand the yarn with the feed side facing up in a basket (snugly). The afghan was on the Lion Brand website. It was my first knitted afghan, and I made it for my best friend who taught me how to do a rag quilt.
Once you got used to the huge needles, it was pretty easy. Straight stockinette all the way through.
She liked it so much, she asked me to teach her how to do it, so she could make another one!
Here is the link: