In most socks, the pattern calls for you to work the gusset until you have the original number of stitches that you started with. If you started with 44 sts, you would usually work the gusset until you had 22 stitches on the heel needles and 22 stitches on the instep needle(s). If you're working more or fewer decreases, you will no longer have the same number of stitches on both the "bottom" of the sock (the heel) and the "top" of the sock (the instep).
In your case, you now have 22 stitches on the top and 20 on the bottom; by redistributing stitches appropriately, I meant that you will need to move stitches so that you have the same number on the top and on the bottom. This needs to be done before you begin the toe decreases so that the top and bottom of the toe are the same width, important if you're going to use the kitchener stitch to close your toe. Right now, the top of your sock is 2 stitches wider than the bottom. If you are going to be doing the kitchener stitch to close your toe, your stitches on the top and bottom won't match up, either. (This will make more sense once you get to the toe.) I'm not sure if a couple of stitches will make much of a difference if you're doing a different type of toe, though. I'm a kitchener stitch sort of gal, myself!
I've found that decreasing down to a total number of stitches that is divisible by 4 is easiest to handle for me because it enables me to redistribute those stitches evenly on both sides.
Does what I said make sense, or did I just muddy the waters more!