I've tried it all (ok, not all but a lot!). Cuff down on dpns, toe-up on dpns and finally, toe-up, magic loop, 2 at a time. This is the method that gets my vote and is the most likely to result in an actual pair of socks as opposed to just a sock. I have not been bitten by the sock bug but I am groovin' on the ML method.
(Silver, you are the sock goddess!)