After looking at the 6-hour afghan pattern, I had to see if I liked the look with the speed stix...but, the largest I have is 35s. So, I took 2 strands (different colors) of my Homespun, cast on a dozen stitches and made a little swatch. Wow...really soft...it'll make a great cuddle.
It's pretty "holey" with the 35s, I think the size 50s would be bigger than I'd like. But, I may just make it on the 35s; maybe with 3 or 4 strands, though. That should make them less "holey"...right?